Phytochemical and synthetic studies on Stemona alkaloids...

来自 : cpfd.cnki.com.cn/Article/CPFDT 发布时间：2021-03-24

Stephen G. Pyne K. B. Lindsay P. Mungkornasawakul A. Jatisatienr 【摘要】：正 The Stemona group of alkaloids includes more than 40 different natural products that have been structurally classified into five different groups. The pyrrolo[1,2-a]azepine A,B-ring structure is common to all compounds in these groups, including the Stemona alkaloids, stemofoline (1) and croomine (2). Extracts of the roots of Stemona species have been used in traditional Chinese medicine for the treatment of various respiratory diseases and as anthelmintic agents for domestic animals. More recently, extracts and the pure alkaloids derived from the extracts of the leaves and roots of 5. collinsae and S. tuberosa were shown to have insect toxicity, antifeedent, and repellent activities.This talk will highlight our recent work on the isolation and structure determination and biological activity of 3 novel Stemona alkaloids from the root extracts of 5. curtisii growing in southern Thailand.I will also report on our synthetic studies aimed at the synthesis of croomine (2).
The pyrrolo[1,2-a]azepine A,B-ring structure is common to all compounds in these groups, including the Stemona alkaloids, stemofoline (1) and cro...Phytochemical and synthetic studies on Stemona alkaloids